E' sufficiente che copi da una applicazione con attivo ajax le giuste sezioni del web.config. Come questo "malloppo":
<?xml version="1.0"?>
<configuration>
<!-- Per ajax -->
<configSections>
<sectionGroup name="system.web.extensions"
type="System.Web.Configuration.SystemWebExtensionsSectionGroup,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35">
<sectionGroup name="scripting"
type="System.Web.Configuration.ScriptingSectionGroup, System.Web.Extensions,
Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35">
<section name="scriptResourceHandler"
type="System.Web.Configuration.ScriptingScriptResourceHandlerSection,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35" requirePermission="false"
allowDefinition="MachineToApplication"/>
<sectionGroup name="webServices"
type="System.Web.Configuration.ScriptingWebServicesSectionGroup,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35">
<section name="jsonSerialization"
type="System.Web.Configuration.ScriptingJsonSerializationSection,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35" requirePermission="false"
allowDefinition="Everywhere" />
<section name="profileService"
type="System.Web.Configuration.ScriptingProfileServiceSection,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35" requirePermission="false"
allowDefinition="MachineToApplication" />
<section name="authenticationService"
type="System.Web.Configuration.ScriptingAuthenticationServiceSection,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35" requirePermission="false"
allowDefinition="MachineToApplication" />
</sectionGroup>
</sectionGroup>
</sectionGroup>
</configSections>
...
<system.web>
<compilation debug="false">
<assemblies>
<add assembly="System.Design, Version=2.0.0.0, Culture=neutral,
PublicKeyToken=B03F5F7F11D50A3A"/>
<add assembly="System.Web.Extensions, Version=1.0.61025.0,
Culture=neutral, PublicKeyToken=31bf3856ad364e35"/>
</assemblies>
</compilation>
<pages>
<controls>
<add tagPrefix="asp" namespace="System.Web.UI"
assembly="System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35"/>
</controls>
</pages>
<httpHandlers>
<remove verb="*" path="*.asmx"/>
<add verb="*" path="*.asmx" validate="false"
type="System.Web.Script.Services.ScriptHandlerFactory,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35"/>
<add verb="*" path="*_AppService.axd" validate="false"
type="System.Web.Script.Services.ScriptHandlerFactory,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35"/>
<add verb="GET,HEAD" path="ScriptResource.axd"
type="System.Web.Handlers.ScriptResourceHandler, System.Web.Extensions,
Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35"
validate="false"/>
</httpHandlers>
<httpModules>
<add name="ScriptModule" type="System.Web.Handlers.ScriptModule,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35"/>
</httpModules>
</system.web>
<system.web.extensions>
<scripting>
<webServices>
</webServices>
</scripting>
</system.web.extensions>
<system.webServer>
<validation validateIntegratedModeConfiguration="false"/>
<modules>
<add name="ScriptModule" preCondition="integratedMode"
type="System.Web.Handlers.ScriptModule, System.Web.Extensions,
Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35"/>
</modules>
<handlers>
<remove name="WebServiceHandlerFactory-Integrated" />
<add name="ScriptHandlerFactory" verb="*" path="*.asmx"
preCondition="integratedMode"
type="System.Web.Script.Services.ScriptHandlerFactory,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35"/>
<add name="ScriptHandlerFactoryAppServices" verb="*"
path="*_AppService.axd" preCondition="integratedMode"
type="System.Web.Script.Services.ScriptHandlerFactory,
System.Web.Extensions, Version=1.0.61025.0, Culture=neutral,
PublicKeyToken=31bf3856ad364e35"/>
<add name="ScriptResource" preCondition="integratedMode"
verb="GET,HEAD" path="ScriptResource.axd"
type="System.Web.Handlers.ScriptResourceHandler, System.Web.Extensions,
Version=1.0.61025.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35" />
</handlers>
</system.webServer>
</configuration>