<Window x:Class="PBEdPallets.Views.MenuPrincipale"
        xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
        xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
        xmlns:d="http://schemas.microsoft.com/expression/blend/2008"
        xmlns:mc="http://schemas.openxmlformats.org/markup-compatibility/2006"
        xmlns:local="clr-namespace:PBEdPallets.Views"
        xmlns:prism="http://prismlibrary.com/"
        prism:ViewModelLocator.AutoWireViewModel="True"
        mc:Ignorable="d"
        Title="Menu Principale:" Height="600" Width="850">
    <Grid>
        <Grid.RowDefinitions>
            <RowDefinition Height="30"/>
            <RowDefinition Height="*"/>
        </Grid.RowDefinitions>
        <Menu Grid.Row="0" x:Name="MenuItems" Height="19" Margin="5,5,5,0" VerticalAlignment="Top">
            <MenuItem Header="Anagrafiche">
                <MenuItem Header="Materiali" Command="{Binding NavigateCommand}" CommandParameter="Editor_AnaMateriali"/>
                <MenuItem Header="Sottocataste" Command="{Binding NavigateCommand}" CommandParameter="Editor_AnaSottocataste"/>
                <MenuItem Header="Tipi livelli pile" Command="{Binding NavigateCommand}" CommandParameter="Test"/>
            </MenuItem>
        </Menu>

        <ContentControl Grid.Row="1" prism:RegionManager.RegionName="ContentRegion" />
    </Grid>
</Window>

using Prism.Unity;

using Microsoft.Practices.Unity;
using PBEdPallets.Views;
using System.Windows;

namespace PBEdPallets
{
    public class Bootstrapper : UnityBootstrapper
    {
        protected override DependencyObject CreateShell()
        {
            //Importo la finestra di avvio.
            return Container.Resolve<MenuPrincipale>();
        }

        protected override void InitializeShell()
        {
            Application.Current.MainWindow.Show();
        }

        protected override void ConfigureContainer()
        {
            base.ConfigureContainer();

            //Container.RegisterType(typeof(object), typeof(Editor_AnaMateriali), "Editor_AnaMateriali");
            //Container.RegisterType(typeof(object), typeof(Editor_AnaSottocataste), "Editor_AnaSottocataste");

            Container.RegisterTypeForNavigation<Editor_AnaMateriali>("Editor_AnaMateriali");
            Container.RegisterTypeForNavigation<Editor_AnaSottocataste>("Editor_AnaSottocataste");
            Container.RegisterTypeForNavigation<Test>("Test");
        }
    }
    
    public static class UnityExtensions
    {
        public static void RegisterTypeForNavigation<T>(this IUnityContainer container, string name)
        {
            container.RegisterType(typeof(object), typeof(T), name);
        }
    }
}

using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;
using System.Threading.Tasks;
using Prism.Commands;
using Prism.Mvvm;
using Prism.Regions;

namespace PBEdPallets.ViewModels
{
    public class MenuPrincipaleViewModel: BindableBase  
    {
        private readonly IRegionManager _regionManager;
        public DelegateCommand<string> NavigateCommand { get; set; }

        #region Costruttore

        public MenuPrincipaleViewModel(IRegionManager regionalManager)
        {
            _regionManager = regionalManager;
            //Definisco l'istanza di NavigateCommand.
            NavigateCommand = new DelegateCommand<string>(Navigate);
        }

        #endregion Costruttore

        #region Private Methods
        private void Navigate(string uri)
        {
            try
            {
                //ContentRegion è il nome assegnato nel tag ContentControl
                _regionManager.RequestNavigate("ContentRegion", new Uri(uri, UriKind.Relative));
            }

            catch (Exception)
            {
                throw;
            }
        }

        #endregion Private Methods
    }
}